Human T-Cell Leukemia Virus Type 1 Tax Dysregulates -Catenin Signaling
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چکیده
Human T-Cell Leukemia Virus Type 1 Tax Dysregulates -Catenin Signaling Mariko Tomita, Akira Kikuchi, Tetsu Akiyama, Yuetsu Tanaka, and Naoki Mori* Division of Molecular Virology and Oncology, Graduate School of Medicine, and Division of Immunology, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan; Department of Biochemistry, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan; and Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
منابع مشابه
Human T cell leukemia virus type 1 Tax inhibits innate antiviral signaling via NF-kappaB-dependent induction of SOCS1.
Human T cell leukemia virus type 1 (HTLV-1) inhibits host antiviral signaling pathways although the underlying mechanisms are unclear. Here we found that the HTLV-1 Tax oncoprotein induced the expression of SOCS1, an inhibitor of interferon signaling. Tax required NF-κB, but not CREB, to induce the expression of SOCS1 in T cells. Furthermore, Tax interacted with SOCS1 in both transfected cells ...
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Human T cell leukemia virus type 1 (HTLV-1) inhibits host antiviral signaling pathways although the underlying mechanisms are unclear. Here we found that the HTLV-1 Tax oncoprotein induced the expression of SOCS1, an inhibitor of interferon signaling. Tax required NFB, but not CREB, to induce the expression of SOCS1 in T cells. Furthermore, Tax interacted with SOCS1 in both transfected cells an...
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The mechanisms by which the human T-cell leukemia virus type I (HTLV-I) Tax oncoprotein deregulates cellular signaling for oncogenesis have been extensively studied, but how Tax itself is regulated remains largely unknown. Here we report that Tax was negatively regulated by PDLIM2, which promoted Tax K48-linked polyubiquitination. In addition, PDLIM2 recruited Tax from its functional sites into...
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تاریخ انتشار 2006